Understanding a newly discovered way cells repair damage to DNA
Drugs that target the way cancer cells repair damage to their DNA have rapidly become successful at treating many different types of cancer. Simply put, too much DNA damage and the cell will die, so by blocking repair in cancer cells you can make them susceptible to DNA damaging agents such as chemotherapy.
Dr Ludovic Deriano and his team at Institut Pasteur, Paris, France, recently discovered two new genes, which play an important role in controlling DNA repair. They now want to discover exactly how these genes help to repair damage to DNA and reveal a novel molecular mechanism that could be used as a new therapeutic target for cancer.