Targeting bone disease in myeloma
Dr Goodyear will use his Worldwide Cancer Research grant to investigate what he thinks could be a new way of preventing myeloma cells from causing bone damage. His laboratory has discovered a type of antibody complex, called SIC, that is able to dock onto the surface of the bone-damaging cells and quench their activity. He will test this potential new treatment in a mouse model of myeloma, and investigate whether it might also help stop the myeloma itself as well as control the bone damage.
If successful, this line of research might not only lead to a new treatment for myeloma, it could also be important for other cancers that often spread to the bone, like breast and prostate cancer.