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Designing a new drug against pancreatic cancer

  • Researcher: Dr Sharon Rossiter
  • Institution: University of Hertfordshire
  • Award Amount: £98,754 for 3 years from January 2013
  • Cancer Type: Pancreatic Cancer
Designing a new drug against pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer that very few people survive from. No effective treatment has been found to treat people with this disease. A protein, called the calcium binding protein S100P, is involved in the growth, survival, movement, and invasion of cells into other tissues. Large amounts of this protein can be found in PDAC, and are also associated with low survival numbers in several other cancers. It may be possible to develop a treatment against PDAC by using S100P.

Dr Rossiter and her team will use their Worldwide Cancer Research grant to find new chemotherapy drugs for pancreatic cancer, which are specifically aimed at attaching to and stopping S100P. This research will combine computer based drug design to better understand the different molecules that drug compounds could potentially attach themselves to, as well as established tests with cancer cells that have the S100P protein. They expect that this will identify the best possible drug compounds for later testing in animal models, which can hopefully be developed into suitable chemotherapy treatments for patients with pancreatic cancer.
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