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Disrupting a cellular communication network

  • Researcher: Dr Thomas Vaccari
  • Institution: University of Milan, Italy
  • Award Amount: £202,540 for 3 years from 1st January 2018
  • Cancer Type: General Cancer Research
Disrupting a cellular communication network
Dr Thomas Vaccari at the Department of Biosciences of the University of Milan in Italy, is using funding from Worldwide Cancer Research to identify weaknesses in a specific cellular communication network, called Notch signalling, which is implicated in a variety of cancers.

His team are using fruit flies to understand more about how this communication network functions. The gene Notch was discovered in the fruit fly but it turned out that the role it plays in normal development, growth, and even in the generation of tumours, is similar to the role it plays in humans. Dr Vaccari hopes that their research will reveal more information about the biological processes that Notch controls, which will ultimately lead to the discovery of a better understanding of its role in cancer.
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