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Dissecting the Myc signalling pathway, a driver of lymphoma growth

  • Researcher: Dr Arianna Sabo'
  • Institution: Istituto Italiano di Tecnologia (IIT), Genova, Italy
  • Award Amount: £184,965 for 3 years from 1st September 2015
  • Cancer Type: Non-Hodgkin's Lymphoma
Dissecting the Myc signalling pathway, a driver of lymphoma growth
Dr Arianna Sabo' is investigating the role of Myc in lymphomas.  Myc is a protein that sticks to DNA.  It can regulate thousands of genes, thereby controlling key cellular processes, such as cell growth, division and death. It is not difficult to imagine that when the amount of Myc in a cell is not carefully controlled, such as in cancer cells where it is frequently excessively high, it can lead to aberrant behaviors, such as unconstrained cell growth and proliferation. Dr Sabo' told us “We are aiming to identifying critical downstream genes regulated by Myc that are selectively activated in cancer cells opposed to normal cells.  These genes will thereby provide us with new therapeutic targets for the elimination of Myc-driven tumours whilst unharming healthy cells.”
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