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Do cancer cells rearrange the information stored in our genes?

  • Researcher: Dr Claudia Ghigna
  • Institution: Istituto di Genetica Molecolare del CNR (IGM-CNR)
  • Award Amount: £102,666 for 4 years from September 2011
  • Cancer Type: General Cancer Research
Do cancer cells rearrange the information stored in our genes?
Dr Claudia Ghigna is using her Worldwide Cancer Research grant to investigate how alternative splicing is involved in angiogenesis, the process through which a tumour can grow its own blood supply to enable enough oxygen and nutrients to reach the cells and allow tumours to grow. Alternative splicing is a mechanism that rearranges information as it is being read from the blueprints stored in the DNA inside our cells. The DNA is coded instructions to make proteins that then carry out activities within the cell. Through alternative splicing cells can make different versions of proteins. With her grant from Worldwide Cancer Research Dr Ghinga will investigate whether cancer cells use alternative splicing as a way to control angiogenesis.
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