FGFR-dependent tumour cells and how they develop resistance
- Researcher: Dr Simon Cook
- Institution: Babraham Institute
- Award Amount: £194,819 for 3 years from Macrh 2013
- Cancer Type: General Cancer Research
Dr Cook and his research team have identified stomach, bladder, and breast cancer cells that need FGFR to multiply or survive. The growth of these tumour cells is blocked by new drugs that are able to stop FGFR proteins delivering signals that tell tumours to grow. He will use his Worldwide Cancer Research grant to investigate the mechanisms that cause the growth and multiplication of breast and stomach cancer cell lines that are addicted to FGFR proteins, and how those mechanisms respond to new drugs that block FGFR, and will aim to identify the genes that are involved in resistance to the drugs; such genes might be useful for developing new drugs in the future.
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