Worldwide Cancer Research Menu

Gene-editing stem cells to improve immunotherapies

  • Researcher: Dr Pierre Guermonprez
  • Institution: Kings College London, UK
  • Award Amount: £242,312 for 3 years from 1st March 2018
  • Cancer Type: General Cancer Research
Gene-editing stem cells to improve immunotherapies
Immunotherapies for cancer are hot topic at the moment. And if you follow the news you’ll know gene-editing using the recently discovered CRISPR technology is also high on the agenda. Dr Pierre Guermonprez, based at King’s College London, is interested in using a bit of both with his grant from Worldwide Cancer Research.

Dr Guermonprez and his team want to see if they can use gene-editing to technology to engineer a special type of immune cell, called a dendritic cell, which could be used to help boost a person’s immune system in order to make other treatments work more effectively. They plan to develop new laboratory methods for coaxing stem cells (these cells are capable of becoming any cell in the body) to turn into dendritic cells that could be used for therapy. Using this method they will then be able to tweak the genetics of the stem cells using CRISPR to see if they can produce dendritic cells that are able to induce a strong immune response. The development of these novel techniques will hopefully pave the way for the development of a new type of cancer therapy that could bolster the strength of other drugs.
Showing: All projects

The Research That Is Happening Right Now

Explore current projects to see how far-reaching our research is from a global perspective.

Projects per page: 31020

Our Impact

See the difference our research projects make.

Our philosophy is very simple: if we believe a project can make a difference in the fight against cancer then we will award a grant to make it happen. We’re not interested in national borders or any kind of geographical bias, just the most promising proposals. And that’s the very reason we ask t...
Read more
Life in the Lab
Supporters often ask us what type of projects their donations are funding. What does a typical day in the life of a cancer researcher look like? To answer these questions and give you an insight into the vital work your support helps us to fund, we've put together this short video....
Read more