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How do cells stop and have a rest?

  • Researcher: Dr David Bernard
  • Institution: CNRS
  • Award Amount: £122,067 for 3 years from June 2011
  • Cancer Type: General Cancer Research
How do cells stop and have a rest?
Healthy cells grow and divide in a highly organised and tightly controlled manner in a process called the cell cycle. Cancer occurs when the DNA gets damaged and the cells become able to multiply in an uncontrolled manner, leading to the development of tumours. One way cells are able to protect themselves if their DNA becomes damaged is by stopping dividing and entering a "rest" phase. Dr Bernard has found that a molecule called PLA2R1 is involved in enabling cells to enter this rest phase and has other anti-cancer roles. Dr Bernard is using his Worldwide Cancer Research grant to further investigate these roles and to understand the mechanism behind them.
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