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How does damaged DNA get repaired?

  • Researcher: Dr Mauro Modesti
  • Institution: Centre de Recherche en Cancerologie de Marseille
  • Award Amount: £178,264 for 4 years from October 2009
  • Cancer Type: General Cancer Research
How does damaged DNA get repaired?

Cancer can be caused by damage to the DNA which makes up our genes. This damage can be due to many things such as UV from sunlight or chemicals in cigarette smoke. Our cells have mechanisms which can detect and repair this damage to prevent diseases such as cancer from occurring. Dr Modesti is investigating how cells repair this DNA damage by a process known as homologous recombination. One protein that has an important role in this process is RAD51AP1 but how and when it is involved is unknown and so this is the focus of Dr Modesti's Worldwide Cancer Research funded work.

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