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Identifying what drives lung squamous cell carcinoma

  • Researcher: Dr Kate Sutherland
  • Institution: The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
  • Award Amount: £259,586 for 3 years from January 2014
  • Cancer Type: Lung Cancer
Identifying what drives lung squamous cell carcinoma
Lung cancer is the leading cause of cancer deaths worldwide. Dr Kate Sutherland is using her Worldwide Cancer Research grant to study a type of lung cancer called squamous cell carcinoma (SqCC). In order to study the disease in a living system she will begin by developing a strain of mouse which mimics the human disease as accurately as possible. This will ensure that any findings she makes will be relevant to patients. Previous investigations looking at the genetic make-up of lung cancer tissue from patient samples have identified a range of mutations involved in lung cancer. However, it is unclear which are the initial mutations that cause the onset of cancer, and which occur later. It is important to identify these so new treatments can be developed to stop the initiation of cancer. Dr Sutherland aims to find which genetic mutations cause the cancer to begin firstly using lab based techniques then validate her findings using her new strain of mice and tissue samples taken from lung cancer patients.
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