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Investigating genes involved in acute myeloid leukaemia

  • Researcher: Professor Claus Nerlov
  • Institution: University of Oxford
  • Award Amount: £212,400 for 3 years from June 2011
  • Cancer Type: Leukaemia
Investigating genes involved in acute myeloid leukaemia
For some time it has been known that leukaemia goes through several early stages, first as non-cancerous pre-stem cells, then leukaemia stem cells and finally becoming leukaemia cells. Professor Nerlov is using his Worldwide Cancer Research grant to investigate the stem cells of a specific type of leukaemia called acute myeloid leukaemia (AML). Professor Nerlov has previously identified genes that are turned off in AML leukaemia stem cells. He is now trying to pinpoint which of these genes has anti-cancer properties and therefore allows the development of AML when it is turned off. In the future this information could be helpful when developing new treatments against this type of cancer.
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