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Investigating how and why our chromosomes can break

  • Researcher: Professor Roberto Chiarle
  • Institution: University of Turin
  • Award Amount: £170,900 for 3 years from January 2012
  • Cancer Type: General Cancer Research
Investigating how and why our chromosomes can break
All of the information that our cells require is carried in coded instructions in our DNA. The DNA is packaged into long, sausage-shaped structures called chromosomes. Sometimes parts of one chromosome can break off and join on to another chromosome. This can be very bad as it can encourage pro-cancer genes to be turned on in an inappropriate manner, allowing the onset or progression of cancer. Professor Chiarle is using his Worldwide Cancer Research grant to study how and when these breaks can occur and their role in cancer.
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