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Investigating new mutations in melanoma

  • Researcher: Professor Brian Gabrielli
  • Institution: University of Queensland
  • Award Amount: £239,467 for 3 years from June 2012
  • Cancer Type: Skin Cancer
Investigating new mutations in melanoma
Melanoma is the most dangerous type of skin cancer that is often associated with exposure to the sun or sunbeds. It is one of the most common causes of cancer in people aged 15-44, although incidences of the disease increase steadily with age.

Professor Gabrielli will be using his Worldwide Cancer Research grant to study new genome mutations that have been associated with melanoma. The genome consists of all the information that is needed to build and maintain a living organism. Advances in technology has allowed for more and more entire genomes to be studied, and increasing numbers of mutations are being identified in the 50 cancer genomes that are currently being analysed worldwide. Many of the mutations are uncommon, and therefore researchers are unsure of whether they play a role in cancer formation. The project will involve analysis of 250 new mutations that are found in melanomas, to identify those that directly lead to disease occurrence.
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