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Investigating the control checkpoints within our cells

  • Researcher: Dr Danny Huang
  • Institution: Beatson Institute for Cancer Research
  • Award Amount: £165,590 for 3 years from June 2012
  • Cancer Type: General Cancer Research
Investigating the control checkpoints within our cells
Cancer can be caused by damage to the DNA inside our cells. This damage can be due to many things such as UV from sunlight or the DNA can become altered or damaged as it is being copied when the cells are growing and dividing to form new cells. All cells have mechanisms to detect and repair this DNA damage, to prevent them becoming cancerous. These detection and repair mechanisms can sometimes become altered or faulty which allows the DNA damage to remain, allowing the cells to become cancerous and tumours to develop. Dr Danny Huang is using his Worldwide Cancer Research grant to study a molecule involved in these mechanisms called Chk1. In particular he will be investigating which other molecules Chk1 interacts with and how they control whether Chk1 is turned on or off. Dr Huang hopes that his findings will help researchers understand how damaged DNA can be allowed to remain and its role in cancer progression.
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