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Investigating the hippo pathway in cancer

  • Researcher: Dr Maria Mione
  • Institution: Karlsruhe Institute of Technology
  • Award Amount: £139,563 for 3 years from October 2012
  • Cancer Type: General Cancer Research
Investigating the hippo pathway in cancer
Cells control all their activities with an internal network of genes and proteins, which are organised into a series of different pathways, each controlling a group of activities such as cell growth or death. Many of these genes and proteins are altered in cancer cells and therefore operate quite differently, causing the cells to grow and divide rapidly, forming a tumour. A group of genes called the Ras genes are known to be altered in cancer cells and once altered; they can then affect many other pathways. One of these is the hippo pathway, an important regulator of tissue growth, but how Ras affects it is unclear. Using zebrafish as a model system Dr Mione is investigating how altered Ras controls the hippo pathway in cancer cells.
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