Worldwide Cancer Research Menu

Investigating the rare bone cancer, Ewing’s Sarcoma

  • Researcher: Dr Maria Paola Paronetto
  • Institution: Fondazione Santa Lucia, Rome, Italy
  • Award Amount: £108,090 for 3 years from January 2014
  • Cancer Type: Ewing's Sarcoma
Investigating the rare bone cancer, Ewing’s Sarcoma
Dr Maria Paola Paronetto is investigating a very rare type of cancer called Ewing’s Sarcoma (ES) which is commonly found in teenagers and young adults.  It can develop anywhere in the body, although it most often starts in the bone.  If caught early, before it has spread, 70% of patients survive for at least 5 years after diagnosis but that means 30% of patients don’t survive for 5 years after diagnosis.  The survival rate also decreases the more advanced the disease is when diagnosed.It is thought that ES may be related to rapid bone growth, hence why it is more common in growing teenagers, but its exact causes are still unclear and need further research.  Some chromosomes are able to break away and fuse with other chromosomes, creating a potent cancer-causing gene that is thought to drive ES.  Dr Paronetto is using her Worldwide Cancer Research grant to further investigate, at the molecular level, the proteins and pathways involved in the initiation of ES.  She hopes to identify pathways or proteins that could be targeted by new therapeutic approaches in the future and help increase the survival rates for ES patients.
Showing: All projects

The Research That Is Happening Right Now

Explore current projects to see how far-reaching our research is from a global perspective.

Projects per page: 31020

Our Impact

See the difference our research projects make.

Our philosophy is very simple: if we believe a project can make a difference in the fight against cancer then we will award a grant to make it happen. We’re not interested in national borders or any kind of geographical bias, just the most promising proposals. And that’s the very reason we ask t...
Read more
Life in the Lab
Supporters often ask us what type of projects their donations are funding. What does a typical day in the life of a cancer researcher look like? To answer these questions and give you an insight into the vital work your support helps us to fund, we've put together this short video....
Read more