Macrophages and Dendritic cells in cancer
- Researcher: Professor John Trowsdale
- Institution: University of Cambridge
- Award Amount: £175,694 for 3 years from January 2013
- Cancer Type: General Cancer Research
Epithelial cells are a layer of cells that cover the surfaces of most of the different organs and tissues inside the body. Most types of cancer are formed from epithelial cells. Professor Trowsdale and his team have found a molecule, which is found on the surface of epithelial tumour cells. This molecule reacts with a protein called LILRB3, which is found on macrophages and dendritic cells, and it stops these immune cells from recognising tumour cells. They are planning on using their Worldwide Cancer Research grant to find a way to learn more about how these molecules interact. They will also try to find a way to stop the tumour molecule from attaching to LILRB3. If this is successful, the tumour cells are no longer protected from macrophages and dendritic cells, and the immune system may help to destroy the tumour.
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