Probing a group of proteins to develop novel ways to detect and treat cancer
- Researcher: Professor Edward Tate
- Institution: Imperial College London
- Award Amount: £199,481 for 3 years from 1st July 2019
- Cancer Type: Ovarian Cancer, Pancreatic Cancer, Prostate Cancer
Professor Edward Tate, based at Imperial College London, is a chemical biologist who through his career has developed techniques to produce chemical probes to study the activity of proteins within cells. These probes allow scientists to measure how active specific proteins are in cancer cells and use this information to develop new ways to diagnose and treat cancer.
Professor Tate is now developing probes to study the activity of KLKs in prostate, ovarian and pancreatic cancer cells. His team will use their results to identify chemicals that can block KLKs in these cells with the goal to open up new avenues for cancer treatment. They will also test the probes in biological samples from cancer patients to understand if measuring KLKs could be used as a way to more accurately diagnose patients.
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