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Profiling a potential new cancer gene

  • Researcher: Dr Gareth Inman
  • Institution: University of Dundee, Scotland
  • Award Amount: £201,316 for 3 years from June 2014
  • Cancer Type: General Cancer Research
Profiling a potential new cancer gene
Dr Gareth Inman at the University of Dundee in Scotland is using his funding from Worldwide Cancer Research to profile a potentially new cancer gene in the lab. He plans to use a range of molecular, biochemical and biological techniques to investigate the gene in cancer cells and patient tumour samples. His aim is to map in detail how this gene could affect cancer progression. What many of our genes actually do is still a mystery. Some of these genes have little more than a temporary name marking their position in our DNA. But one of these genes could turn out to be the next big target for treating cancer. That’s why Dr Inman and his team are investigating this little known gene. They first identified the gene as one of many targeted by a cancer-linked molecule called TGF-beta. In addition, they have already gathered evidence showing that through TGF-beta, this new gene is involved in basic mechanisms associated with cancer progression, such as cell growth and movement. Evidence also suggests it could be linked to many cancers, including breast cancer, ovarian cancer, myeloma, liver cancer, and lung cancer. If Dr Inman can pin down exactly how this gene might be involved in cancer, it could open up potentially new and unexplored therapeutic opportunities.
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