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Researching the mechanisms that allow cancer to occur

  • Researcher: Dr Gareth Inman
  • Institution: University of Dundee
  • Award Amount: £202,807 for 3 years from August 2011
  • Cancer Type: General Cancer Research
Researching the mechanisms that allow cancer to occur
Healthy cells grow and divide in a tightly controlled manner. Cancer occurs when the cells become able to multiply in an uncontrolled manner, leading to the development of tumours. Dr Inman is using his Worldwide Cancer Research grant to study a protein called TGF-beta which he has previously shown to have anti-tumour properties and helps ensure cells divide correctly. However, during the growth of some tumours they are able to switch TGF-beta from being anti-cancer to pro-cancer but how, when and where this occurs is still unclear. Dr Inman is now investigating this important switch further to try to understand the mechanisms behind it.
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