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Shutting off cancer’s energy supply

  • Researcher: Dr Angel Nebreda
  • Institution: Institute for Research in Biomedicine, Barcelona, Spain
  • Award Amount: £199,500 for 3 years from 1st January 2018
  • Cancer Type: General Cancer Research
Shutting off cancer’s energy supply
Dr Angel Nebreda and his team at the IRB in Barcelona are using funding from Worldwide Cancer Research to find out how cancer cells get their energy so that they can find ways to shut them down. Cancer cells are known to obtain their energy through different mechanisms to normal cells so understanding how they do it could reveal new ways to develop targeted treatments.

The team are particularly interested in a protein called p38-alpha MAPK, which they have begun to show plays a central role in the survival of cancer cells. They now want to study in greater detail exactly how this protein helps cancer cells to produce the energy they need to grow and divide and what happens to cancer cells if they try and block it off.
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