Worldwide Cancer Research Menu

Stopping Kaposi’s Sarcoma-associated herpes virus (KSHV) in its tracks

  • Researcher: Dr Adrian Whitehouse
  • Institution: University of Leeds, Leeds, England
  • Award Amount: £199,737 for 3 years from 1st October 2016
  • Cancer Type: Kaposi's Sarcoma
Stopping Kaposi’s Sarcoma-associated herpes virus (KSHV) in its tracks
Professor Adrian Whitehouse is finding new ways to stop the virus which causes Kaposi’s sarcoma- a rare form of cancer affecting the skin and internal organs. The virus, known as KSHV, can cause Kaposi’s sarcoma in people with weakened immune systems. People who have AIDS or have had an organ transplant for example can be especially vulnerable. “We currently don’t have any form of antiviral or vaccine to fight KSHV,” says Professor Whitehouse. “Meanwhile Kaposi’s sarcoma is becoming more and more common in some parts of the world. For example, because of the AIDS epidemic, Kaposi’s sarcoma is now the most common reported adult tumour in sub-Saharan Africa.” Professor Whitehouse and his team have been studying exactly how KSHV manipulates the human cells it infects to improve its own survival. “Finding a way to block replication of the virus inside infected cells could be a way to stop Kaposi’s sarcoma developing,” says Professor Whitehouse. “We have exciting early data which suggests that KSHV uses a specialised gene expression mechanism in the cell to replicate its own genetic material. We now need to investigate exactly how and why the virus uses this mechanism- that’s our aim for this project.” “Ultimately we want to find out whether blocking this cell mechanism could potentially be a new antiviral treatment strategy for Kaposi’s sarcoma and other KSHV-associated diseases.”
Showing: All projects

The Research That Is Happening Right Now

Explore current projects to see how far-reaching our research is from a global perspective.

Projects per page: 31020

Our Impact

See the difference our research projects make.

Philosophy
Our philosophy is very simple: if we believe a project can make a difference in the fight against cancer then we will award a grant to make it happen. We’re not interested in national borders or any kind of geographical bias, just the most promising proposals. And that’s the very reason we ask t...
Read more
Life in the Lab
Supporters often ask us what type of projects their donations are funding. What does a typical day in the life of a cancer researcher look like? To answer these questions and give you an insight into the vital work your support helps us to fund, we've put together this short video....
Read more