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Studying the link between obesity and liver cancer

  • Researcher: Professor Tony Tiganis
  • Institution: Monash University
  • Award Amount: £273,118 for 3 years from June 2012
  • Cancer Type: Liver Cancer
Studying the link between obesity and liver cancer
Primary liver cancer is the sixth most common cancer in the world. Most liver cancers start after cancer cells have spread from a different part of the body, this is called secondary cancer. Primary liver cancer, where the liver is the first place that the tumour grows, is one the third most common cause of death from cancers worldwide, and survival rates are very low. Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer, accounting for 90% of cases. HCC is more common in developing countries, where it is associated with long term Hepatitis B infection. HCC has almost doubled in the US & nearly tripled in Australia in the last 20 years, and the obesity epidemic is believed to play a large part in this drastic increase.

Professor Tiganis will be using his Worldwide Cancer Research grant to study the molecular changes that happen within the liver as a result of obesity, and how these molecular changes can lead to HCC.
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