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Tackling treatment resistance

  • Researcher: Dr Michaela Frye
  • Institution: University of Cambridge, England
  • Award Amount: £199,799 for 3 years from January 2015
  • Cancer Type: General Cancer Research
Tackling treatment resistance
Dr Michaela Frye and her team at the University of Cambridge are investigating how cancer cells become resistant to treatment. More than 1 in 3 people in the UK will be diagnosed with some form of cancer during their lifetime.* Cancer is often effectively treated initially, but many patients become resistant to treatment, and there is an urgent need for new therapies that specifically target drug-resistant cancer cells. Dr Frye has gathered evidence that a process called ‘RNA methylation’ may help some healthy cells survive in response to external stresses which damage their DNA. They now want to find out whether the same process might help cancer cells survive treatment, and encourage them to become resistant. “It’s vital that we test whether altering the RNA methylation process in resistant cancers could make them again become sensitive to anticancer drug treatments,” says Dr Frye. “For me, this project is really exciting because it allows us to test truly unexplored pathways for their potential in novel anticancer strategies.” * Latest statistics from Cancer Research UK
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