The role of the MYO5B protein in bowel cancer
- Researcher: Dr Diego Arango
- Institution: Vall d' Hebron Research Institute (VHIR)
- Award Amount: £165,311 for 3 years from January 2013
- Cancer Type: Bowel Cancer
Dr Arango and his team have found that in cases of bowel cancer, a part of the MYO5B gene has an additional molecule attached to it, which affects how the gene works. They will use their Worldwide Cancer Research grant to study how MYO5B affects cancer progression, by studying the genetic changes that delete the protein from bowel cancer cells, and looking at how the presence of the protein might stop tumours from growing. They also plan to study the link between MYO5B and survival of patients at different stages of the disease. This work will hopefully teach us more about what happens within cancer cells at the early stage of development and to see whether the presence or absence of the MYO5B protein can be used as a way to test for bowel cancer.
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