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Understanding how Acute Myeloid Leukaemia cells avoid dying

  • Researcher: Professor David MacEwan
  • Institution: University of East Anglia
  • Award Amount: £193,106 for 3 years from April 2012
  • Cancer Type: Leukaemia
Understanding how Acute Myeloid Leukaemia cells avoid dying
Acute Myeloid Leukaemia (AML) is rare and is most common in people over 65 years old. Current treatments are mainly only suitable for younger and fitter patients, meaning there is a need for better treatments for many patients. Professor MacEwan and his team have recently identified a molecule called Nrf2 which is able to help the cell avoid dying, even when treated with chemotherapy drugs but it is still not clear exactly how it can do this. One theory is that acute myeloid leukaemia cells have high levels of Nrf2. Professor MacEwan is now using his Worldwide Cancer Research grant and samples from patients to fully investigate how Nrf2 is able to cause this protective effect on the acute myeloid leukaemia cells. He hopes that his results could aid the development of better treatments for acute myeloid leukaemia patients in the future.
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