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Understanding how marginal-zone lymphomas start

  • Researcher: Dr Jose A. Martinez-Climent
  • Institution: Fima Fundación Para la Investigación Médica Aplicada, Pamplona, Spain
  • Award Amount: £199,756 from 1st October 2015 for 3 years
  • Cancer Type: Non-Hodgkin's Lymphoma
Understanding how marginal-zone lymphomas start
Lymphomas are cancers of white blood cells, the two main forms being Hodgkin’s Lymphoma and Non-Hodgkin’s Lymphoma.  Dr Jose A. Martinez-Climent is investigating a form of lymphoma called marginal zone lymphomas which are a group of slow growing Non-Hodgkin’s Lymphomas, often diagnosed in people in their sixties and accounting for 10% of all human lymphomas. There are three types of marginal zone lymphomas and a better understanding of the mechanisms involved will allow a better diagnosis of these different subtypes as well as helping to tailor therapies. Dr Martinez-Climent explained “We have found that the molecule NKX2-3 is present at high levels in a third of marginal zone lymphomas and appears to be involved in allowing the cancer cells to spread and form secondary tumours in lymph tissue. They are now using a mouse model of the disease and samples from patients to more fully analyse the role of NKX2-3 in marginal zone lymphomas.” He concluded “We expect that these studies will help pave the way to develop novel therapeutic approaches targeting NKX2-3 in marginal-zone lymphomas.”
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