Worldwide Cancer Research Menu

Understanding how the NF1 gene is involved in tumours of the nervous system

  • Researcher: Professor Alison Lloyd
  • Institution: University College London
  • Award Amount: £234,530 for 3 years from May 2012
  • Cancer Type: Nervous System
Understanding how the NF1 gene is involved in tumours of the nervous system
Neurofibromatosis is an inherited condition which can be passed on from parents to their children. Sufferers tend to develop a number of benign nerve tumours which have a strong risk of developing into more dangerous malignant cancers. Previous animal models have shown that neurofibroma tumours only form when a gene called NF1 is removed at a critical stage in the mice development but it is not clear how well this mimics what occurs in humans. Dr Lloyd has made a new mouse-model where she can remove the NF1 gene in adult mice. This alone does not cause tumours but if the mice also suffer nerve injury the majority of the mice develop tumours along the length of the nerve. Dr Lloyd is using her Worldwide Cancer Research grant to better understand how these tumours occur and she hopes to be able to look for potential ways to treat these tumours in the future.
Showing: All projects

The Research That Is Happening Right Now

Explore current projects to see how far-reaching our research is from a global perspective.

Projects per page: 31020

Our Impact

See the difference our research projects make.

Our philosophy is very simple: if we believe a project can make a difference in the fight against cancer then we will award a grant to make it happen. We’re not interested in national borders or any kind of geographical bias, just the most promising proposals. And that’s the very reason we ask t...
Read more
Life in the Lab
Supporters often ask us what type of projects their donations are funding. What does a typical day in the life of a cancer researcher look like? To answer these questions and give you an insight into the vital work your support helps us to fund, we've put together this short video....
Read more