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Understanding how to treat skin cancer as it progresses

  • Researcher: Professor Xose Bustelo
  • Institution: Foundation for Cancer Research at the University of Salamanca, Spain
  • Award Amount: £191,578 for 3 years from June 2014
  • Cancer Type: Skin Cancer
Understanding how to treat skin cancer as it progresses
Scientists think that if a treatment could be developed to modulate a family of proteins called 'Vav proteins' in skin cancer, it might be used to help stop tumour growth. Professor Bustelo in Spain hopefully now has a way to find out if this is feasible.Professor Bustelo’s group have developed an extremely sophisticated mouse model to study the potential therapeutic value of disrupting Vav proteins at different stages of skin cancer. Using this mouse, Professor Bustelo will be able to mimic and study the potential effects of using Vav blocking drugs in patients with more- or less-advanced disease. Skin cancer is a chaotic and complex disease with multiple interactions between cancer cells, non-cancerous cells, and infiltrating inflammatory cells all happening simultaneously. These cell interactions can also change as the cancer progresses. To develop new and better treatments scientists need to understand what happens at all stages of the disease, and whether treatments will be effective in these different stages. Professor Bustelo’s work using Worldwide Cancer Research funding will now hopefully help scientists move towards new treatments to combat skin cancer.
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