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Understanding the role of LOXL2 in the development of skin and breast cancer

  • Researcher: Professor Amparo Cano
  • Institution: Instituto de Investigacion Sanitaria HULP-IdiPAZ
  • Award Amount: £206,813 for 3 years from September 2012
  • Cancer Type: Breast Cancer
Understanding the role of LOXL2 in the development of skin and breast cancer
One of the main factors making tumours so dangerous is their ability to invade surrounding tissues and organs and spread throughout the body. This is known as metastasis. Individual cancer cells squeeze between the normal cells nearby and push their way through the tissue. They are then carried in the blood stream and can form new tumours in other parts of the body, known as secondary tumours or metastases. In the last decade, significant findings have shed some light on the processes that enable cancer cells to spread. This involved the identification of key molecules for tumour spread.

Professor Cano's research team have previously described the interactions of some of these molecules with a molecule called LOXL2. She will be using her Worldwide Cancer Research grant to reveal the role of a molecule called LOXL2 in tumour development and metastasis. The work will mainly focus on breast and skin tumours.
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