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Understanding the role of the protein ATR in copying DNA

  • Researcher: Professor Noel Lowndes
  • Institution: National University of Ireland Galway, Ireland
  • Award Amount: £204,340 for 3 years from June 2014
  • Cancer Type: General Cancer Research
Understanding the role of the protein ATR in copying DNA
For cells to grown and divide, all the DNA needs to be precisely and accurately copied in order to pass a full and correct version to each of the new daughter cells when the divide. In order to do this there are many complex copying and quality control systems in place inside the cell. Defects in these systems can lead to "replication stress", which is known to contribute to cancer development. A key regulator protein in all of this is ATR, which responds to replicative stress. Professor Noel Lowndes is using his Worldwide Cancer Research grant to investigate the role of ATR in controlling DNA replication in both the absence and presence of replication stress. This type of project is important for scientists to fully understand what happens in normal, healthy cells which, in future, may also help them understand some of the many things that go wrong in cancer cells.
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