Using a tapeworm killer to treat ovarian cancer
- Researcher: Dr Chit Fang Cheok
- Institution: Institute of Molecular and Cell Biology, A*STAR, Singapore
- Award Amount: £99,620 for 2 years from 1st June 2019
- Cancer Type: Ovarian Cancer
Dr Chit Fang Cheok, based at the Institute of Molecular and Cell Biology in Singapore, is testing new use for a drug called niclosamide, commonly used to treat tapeworm infection, to see if it can target high grade serous ovarian cancer cells. Nearly all cases of this ovarian cancer bear a mutation in the p53 gene, which in healthy cells acts as a molecular guardian, protecting the cell from becoming cancerous. Potentially, niclosamide could be effective in eradicating high grade serous ovarian cancer cells that carry a mutant form of p53.
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