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Why do some women with breast cancer respond better than others?

  • Researcher: Professor Joy Burchell
  • Institution: King's College London
  • Award Amount: £220,418 for 4 years from January 2011
  • Cancer Type: Breast Cancer
Why do some women with breast cancer respond better than others?
Many breast cancers require the female sex hormone oestrogen in order to grow and are known as ‘hormone sensitive’ or ‘hormone receptor positive’.  These breast cancers can be treated with drugs that block the effects of oestrogen, such as tamoxifen.  Dr Burchell is investigating the function of a protein called JARID1B which plays a role in hormone receptor positive breast cancer cells.  Low levels of JARID1B are linked to lower survival levels for patients and so Dr Burchell is also studying whether the JARID1B works together with tamoxifen and if so, how.
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