Worldwide Cancer Research Menu

Using worms to improve the use of chemotherapy

  • Researcher: Professor Anton Gartner
  • Institution: University of Dundee, Scotland, UK
  • Award Amount: £200,168 for 2 years from 1st January 2018
  • Cancer Type: General Cancer Research
Using worms to improve the use of chemotherapy
Cisplatin is a widely used chemotherapy drug that works by damaging the DNA of cells to the extent that the cell cannot repair itself and dies. However, even after successful treatment, cancers often return because some of the cancer cells are able to repair the damage caused by cisplatin and survive. Professor Anton Gartner and his team at Dundee University are trying to identify the molecular machinery that cells use to repair damage caused by cisplatin. By doing this they hope it will lead to better ways to identify patients that would benefit the most from the drug.

Professor Gartner is using the microscopic nematode worm (C. elegans) to test how cisplatin interacts with DNA and what happens once damage is induced. These worms are a useful model because they contain only around 1000 cells and their genetics are very well understood. This means the team can easily study the changes that occur to DNA following cisplatin in a whole organism.
Showing: All projects

The Research That Is Happening Right Now

Explore current projects to see how far-reaching our research is from a global perspective.

Projects per page: 31020

Our Impact

See the difference our research projects make.

Our philosophy is very simple: if we believe a project can make a difference in the fight against cancer then we will award a grant to make it happen. We’re not interested in national borders or any kind of geographical bias, just the most promising proposals. And that’s the very reason we ask t...
Read more
Life in the Lab
Supporters often ask us what type of projects their donations are funding. What does a typical day in the life of a cancer researcher look like? To answer these questions and give you an insight into the vital work your support helps us to fund, we've put together this short video....
Read more