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Targeting molecular blips on brain cancer chromosomes

Researcher
Dr Lee Wong
Project period
Jan 2018 - Jan 2020
Country
Research Institute
Monash University
Cancer types
Brain cancer
Dr Lee Wong

Aim of the research

Dr Lee Wong aims to find out how tiny changes in the way DNA is packaged can lead to cancer. This understanding might help to identify weak spots that could be used as targets for treatments in the future.

Meet the scientist

Lee Wong is Professor of Biochemistry and Molecular Biology at Monash University in Melbourne. They want to understand how certain parts of the chromosome, the structure that holds our DNA, are regulated.

More about the research project

DNA - the vital life molecule that contains the genetic code - exists in the nucleus of cells in tightly wound structures called chromosomes. The way the DNA is wound into chromosomes is precise and mistakes in the process are frequently associated with the onset of cancer. This is particularly true for gliomas, or brain tumours.

Dr Wong and her team at Monash University in Australia have worked out that a tiny alteration to chromosome structure can be used to identify tumour cells from normal cells. Using funding from Worldwide Cancer Research and The Brain Tumour Charity, Dr Wong now wants to investigate exactly how these changes drive tumour growth in conditions such as glioma. This work will ultimately identify weaknesses in these cancers that might be able to be hit with targeted treatments.

Co-funder

This project was made possible thanks to a co-funding partnership with The Brain Tumour Charity.