Dr Saveanu trained as a medical doctor - realising how little we knew about some of the illnesses causing suffering in her patients made her realise how important fundamental research is. Outside of the lab, Dr Saveanu loves reading – as a child, she finished all of the books in the children’s section of her town’s library!

T cells are a type of immune cell that can recognise cancer cells. They do this by detecting molecules on the surface of the cancer cell with something called a T cell antigen receptor (TCR). When a T cell detects a cancer cell, the TCR triggers a chain reaction of chemical signals in the cell. These can either lead to the cell becoming a ‘killer T cell’, capable of killing the cancer cell, or instead go ‘blind’ to the cancer cell and ignore it.

It is possible to reverse this blindness with treatments like immunotherapy, but how well it works depends on the chemicals that triggered the blindness in the first place. Dr Saveanu and her team have set out to understand how this process works in more detail, so they can make immunotherapies more effective.

They previously found that, when a T cell detects a cancer cell, the TCR (the structure the T cell uses to detect it) moves into the cell and continues to send out signals. The researchers now want to study the signals it gives off once inside the cell, and how they can make T cells become killer T cells and destroy cancer cells.