Research projects

Bowel cancer is one of the most common cancers worldwide. While survival rates have made an impressive jump in the last 40 years, only slightly more than half of all patients survive for 10 years or longer after their diagnosis. This is in part because bowel cancer often becomes resistant to treatments and there is an urgent need for new ways to tackle this resistance.

Dr Huarte and her team are trying to better understand the behaviour of tumour cells by studying a type of molecule called “long non-coding RNA” (lncRNA). lncRNA can interact with other molecules inside the cell and influence how they behave. In cancer cells, this can contribute to the development of treatment resistance.

Normal cells self-destruct when put under enormous stress, but some cancer cells lose this ability. Re-establishing this ability to self-destruct in cancer cells could be a way to stop cancer from growing. It is thought that lncRNAs are involved in this process, but their role is not very well understood.

Dr Huarte now wants to study the role lncRNAs play in “stressed” cells to better understand the behaviour of cancer cells. These insights could lead to the identification of new ways to develop targeted cancer therapies.