Research projects

Dr Vincenzo Costanzo is both a researcher and clinician. When not working, Dr Vincenzo Costanzo likes to spend his time playing Jazz music as an amateur pianist.

During pregnancy, the placenta – a temporary organ that feeds and protects the foetus – has to attach strongly to the uterus. It does this by invading the wall of the uterus and by connecting to the mother’s blood vessels. At the same time, the cells in the placenta need to make sure that the mother’s immune system doesn’t recognise and attack the foetus’ cells as they are “foreign”. Cancer cells exploit many of the very same abilities when they are invading surrounding tissues, while making sure to not be detected by the body’s immune system.

Every time a cell divides, it needs to copy its entire DNA. Cancer cells divide incredibly rapidly, putting a lot of pressure – or stress – on the machinery that copies its DNA. Dr Vincenzo Costanzo and his team discovered that this replication stress in cancer cells seems to reactivate the same abilities that were present in placental cells. These abilities are usually suppressed in adult cells, as they are only needed during foetal development. The team is now trying to gain a better understanding of how the cancer cell’s stress response is linked to the reactivation of placental abilities and hope that their insights will lead to the discovery of new and effective treatments.