Research projects

Dr Vasiliki Koliaraki has dreamt of being a research scientist since she was 8 years old, when she read “Shannon’s Way” and became fascinated by the passion and determination of scientists. She is motivated every day by the possibility of discovering new knowledge and working out how to take it further. Outside of the lab, Dr Koliaraki enjoys spending time with her family, reading books, drawing, and cooking.

Recent research has shown that the microenvironment of colorectal tumours, as well as many other types of tumour, plays an important part in the growth and spread of cancer. This includes the way that tumours communicate with the healthy cells that surround them, such as recruiting them to help support the tumour’s growth.

NOTCH is a protein found in healthy cells and used as part of an important communication network, relaying molecular signals from outside the cell to the inside. However, higher than normal levels of NOTCH have been found in patients with colorectal cancer and this has been linked to worse outcomes. Research has shown that a key influence on the growth of colorectal tumours could be when the communication network using NOTCH doesn’t work as it should.

Dr Koliaraki and her team previously discovered that colorectal tumours use NOTCH to recruit healthy cells, called fibroblasts, to support the tumour’s growth. The researchers now aim to uncover how colorectal tumours are able to use NOTCH to recruit fibroblasts by studying how this happens in cancer cells in the lab and mice with colorectal cancer. They hope that understanding how this happens will reveal new ways to interrupt this process and stop colorectal tumours growing.